Session 178 - Scale-up Issues in Pharmaceutical Formulation Development


Pharmaceuticals
Session 178 - Scale-up Issues in Pharmaceutical Formulation Development
This session is devoted to the implementation of novel approaches taken to address challenging scale-up issues related to the pharmaceutical industry. Of particular interest would be the discussion of laboratory and pilot-scale work performed to define the critical aspects of the chemical synthesis and/or drug product manufacture and the corresponding approaches to their implementation at larger scales.
Chair:	Michael B. Mackaplow
CoChair:	Mayur P. Lodaya
	178a	The Importance of Using Limiting Flow Rates to Assess the Flowability of Pharmaceuticals, Excipients and Their Mixtures Karl Jacob, James K. Prescott
	178b	An Investigation into the Effects of Binder Viscosity, Shear Rate, Mixing Time, and Primary Particle Size on the Spreading of a Liquid in a Particle Bed Richard Turton, Tyler D. Simmons
	178c	Characterization of Coating Formulation and Process Manufacturing Understanding as Tool for Determination of Coating's Strength Giacomo Perfetti, G.M.H. Meesters, Willem J. Wildeboer, Chantal van der Meer
	178d	Use of Cfd to Identify and Resolve Cell Culture Issues Observed at Production Scale during Technology Transfer Zhiwu Fang
		Break
	178e	Modeling Hot-Melt Extrusion Pelletizers Stefan Radl, Thomas Tritthart, Johannes G. Khinast
	178f	Formulation and Process Development of Atripla® Tablets Mark Menning
	178g	Expedite Development and Commercialization of Pharmaceuticals with Process Modeling and Scheduling Tools Demetri Petrides, Charles Siletti

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Pharmaceuticals