Pharmaceuticals

Session 744 - Science and Engineering in Crystallization
Robust crystallization of API with desired properties often requires a seamless interface between crystallization science and engineering principles. Crystallization science governs the chemical interactions that drive both nucleation and growth. Engineering principles provide the tools for scale-up and finesse the process. In this section, we invite authors to submit papers that apply both science and engineering to solve challenging scale-up problems, such as polymorph and enantiomer crystallization, particle size manipulation, and habit modification, to name a few.
Chair: Hector Guzman
CoChair: Monica H. Lamm
CoSponsor(s): Crystallization and Evaporation
  Linear Models for Prediction of Ibuprofen Crystal Morphology Based on Hydrogen Bonding Propensities
Charles Acquah, Arunprakash T. Karunanithi, Matthew Cagnetta, Luke E. K. Achenie, Steven Suib
  Mechanism of the Formation of Enantiotropic Polymorphs in Solution Crystallization
Wenju Wu
  Polymorph Selection In Solution Crystallization: Is Kinetics the Primary Determinant?
Sendhil K. Poornachary, Guangjun Han, Pui Shan Chow, Reginald B. H Tan
  Mechanistic Model for the Effect of Molecular Imposters on the Shape of Molecular Organic Crystals
Jacob P. Sizemore, M. F. Doherty
  Precise Tailoring of the Crystal Size Distribution by Optimal Seeding Time Profiles
Nicholas Kee, Xing Yi Woo, Reginald B. H Tan, Richard D. Braatz
  Development and Scale-up of a Seeded Acidic Co-Addition Crystallization
Adam S. Butterbaugh, Kevin D. Seibert, Paul C. Collins
  Systematic Design of Supersaturation Controlled Crystallization Processes
Zoltan K. Nagy, Erum AAmir, Chris Rielly

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