Session 521 - Applications of ChEmometrics for Process Development


Process Research and Innovation
Session 521 - Applications of ChEmometrics for Process Development
Innovations in Process Development are empowered by using ChEmometrics techniques to derive useful information from complex data systems. A wide range of chemometrics applications is encompassed in this session, including increased process understanding through optimization of experimental parameters, design of experiments, calibration, signal processing and enhancement of PAT development.
Chair:	James Marek
CoChair:	Jean W. Tom
		Welcoming Remarks
	521a	Introduction to ChEmometrics -- Design of Experiments and Principal Component Analysis Dongsheng Bu, Andrew Chu
	521b	Data Exploration Analysis In Process Development: Application to API Characterization Jose E. Tabora, Jessica Defreese, Prashant Deshpande, Jean Tom
	521c	Scale-up a Complex Pharmaceutical Batch Process Using Mid-IR: The Role of Simple Peak Height Profiling, Partial Least Squares (PLS) Modeling and Dynamic Principal Component Analysis (PCA) Shan Lin, James Marek, Samrat Mukherjee
	521d	Application of ChEmometrics in Process Monitoring of Synthesizing Preferred Isomer Dongsheng Bu, Andrew Chu
	521e	Utilization of Single Crystal X-Ray Studies of Process Relevant Pharmaceutical Crystal Forms to Support Qbd John D. DiMarco, Michael A. Galella, Raymond P. Scaringe, Carolyn J. Pommier, Jack Z. Gougoutas

Process Research and Innovation