micro and nano sized structures as the foundation in the architecture for

precise dosage formulation.

One of the more promising and forward thinking technologies that can be

employed in the design of controlled delivery and precise dosage formulation

is drop on demand technology. The design of robust platform for solid

dosage manufacturing via drop on demand technology requires intimate

knowledge of the phase behavior and morphology of deposited drug/excipient

mixtures. We have studied solidification kinetics of melted polyethylene

glycol (PEG) with various loads of ibuprofen, griseofulvin, and

chlorpropamide deposited on the biopolymer film substrates. It was

determined that drug type, concentration, temperature, substrate film type,

and film concentration have an effect on nucleation, crystallization rate,

evaporation rate, surface energy, and droplet solidification. Wetting

behavior of droplets containing griseofulvin and chlorpropamide on

hydroxypropyl cellulose (HPMC) was measured and controlled through

engineering of surface properties of substrate film and drug loaded PEG.

Wetting behavior differs according to changes in the contact angle caused by

the development of a new solid phase with the density higher than the liquid one.

Research revealed that cooling rate is determining the crystallization

process. Conditions that prevent crystallization and lead to formation of

amorphous material have been found.