There are a number of forces driving the U.S. chemical industry in the 21st century, including shareholder return, globalization, efficient use of capital, faster product development, minimizing environmental impact, improved return on investment, improved and more efficient use of research, and efficient use of people. To achieve these goals, the chemical industry is investigating the expanded use and application of new computational technologies employed in areas such as modeling, computational chemistry, design, control, instrumentation, and operations. The key technology driver over the past 20 years has been the continuing advances in digital computing. A new paradigm that encompasses the process systems engineering (PSE) topics mentioned above is smart process manufacturing, which will require the development of research environments to support such activities, also known as cyberinfrastructure. A research agenda must be developed to provide a coherent and orchestrated effort to achieve the vision of smart process manufacturing. To that end an NSF-sponsored workshop was held on April 21-22, 2008 under a grant to the CACHE Corporation. Details on the research agenda and how the PSE community can participate will be covered in this presentation.