Innovative technology of atmospheric fluidized bed freeze drying for production of pharmaceutical powders with predefined structure
Chemical Product Design and Engineering (CPD&E)
Chemical Product Design & Engineering - Poster (CPD&E - P)
Keywords: innovative technology, atmospheric fluidized bed freeze drying, pharmaceutical powders, predefined structure
A new method of drying process to produce dispersed pharmaceutical powders with nano- and microstructure was suggested: atmospheric fluidized bed freeze drying.
Suggested method is innovative and has the following advantages: intensive heat and mass exchange, and, respectively, high rate of moisture removal, because of active hydrodynamical regime; short-time process; no need to use vacuum; quite low energy consumption; possibility to run process in a continuous mode; effective on-line control of the temperature and moisture content of the material, full saving of it’s biological activity; possibility to produce particles with a regular shape and defined size with porous nano- and microstructure. All these points supply with fast and total rehydration of the product, and also give an opportunity to use the product as an inhalation medicine.
During working the complex of experimental and analytical researches was carried out, that allowed us to figure out the influence of this drying method on shape and structure of particles and quality of product.
Basing on the theory of mechanics of heterogeneous media and nonequilibrium thermodynamics, was worked out a mathematical model of the process, which allowed to calculate parameters of atmospheric fluidized-bed freeze drying for fine-dispersed powders.
Were found out parameters of the process a long the height of the plant for different types of materials and evaluated conditions for plant’s stable mode.
As a lot of moisture is removed intensively during the process, mass of particles decreased very much, this results in releasing particles out of the bed, adhesion of particles on filters and, as a result, ineffective drying of the product. Therefore was solved a problem of regulating the rate of drying agent for supplying a stable hydrodynamical regime during the hole process.
Were given out recommendations on the new design of drying chamber and technological scheme, which was economically proved.
Presented Wednesday 19, 13:30 to 15:00, in session Chemical Product Design & Engineering - Poster (CPD&E - P).
