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Determination of Physiological Modes in Saccharomyces-Cerevisae Culture using Sequential Data Analysis

Authors:Cassar J. Philippe, University of Lille (USTL), France
Guillou Vincent, LSPCMIS (CNRS - UPS Toulouse), France
Topic:8.4 Control of Biotechnological Processes
Session:State Estimation in Bio/Chemical Processes
Keywords: data analysis, monitoring, biological application, and physiological states.

Abstract

Detecting the physiological mode of microorganism during a culture may allow to better handle behaviour modifications that can affect the productivity. This paper proposes a new sequential method that utilises a classification of directions that generate the subspace orthogonal to the pre-processed measurements. Existence of the orthogonal subspace and the nature of pre-processing are derived from theoretical modelling of the culture. An application to a Saccharomyces Cerevisae culture shows the ability to well isolate main biological phases of the process.